“Study delves into the data and highlights potential ways to tackle immunological decline
As people age, their immune systems naturally begin to decline. This aging of the immune system, called immunosenescence, may be an important part of age-related health problems such as cancer and cardiovascular disease, as well as older people’s less effective response to vaccines.
But not all immune systems age at the same rate. In our recently published study, my colleagues and I found that social stress — the stress arising from difficult or challenging circumstances relating to your social position or relationships with other people — is associated with signs of accelerated immune system aging.
Data and immunosenescence
To better understand why people with the same chronological age can have different immunological ages, my colleagues and I looked at data from the Health and Retirement Study, a large, nationally representative survey of U.S. adults over age 50 funded by the National Institute on Aging.
HRS researchers ask participants about different kinds of stressors they have experienced, including stressful life events such as job loss; discrimination, which could mean being treated unfairly or being denied care; major lifetime trauma, such as a family member’s having a life-threatening illness; and chronic stress, such as financial strain.
Recently, HRS researchers have also started collecting blood from a sample of participants, counting the number of different types of immune cells present, including white blood cells. These cells play a central role in the immune responses to viruses, bacteria and other invaders. This is the first time such detailed information about immune cells has been collected in a large national survey.
By analyzing the data from 5,744 HRS participants who both provided blood and answered survey questions about stress, my research team and I found that people who experienced more stress had a lower proportion of “naive” T cells — fresh cells needed to take on invaders the immune system hasn’t encountered before.
They also have a larger proportion of “late differentiated” T cells — older cells that have exhausted their ability to fight invaders and instead produce proteins that can increase harmful inflammation.
People with low proportions of newer T cells and high proportions of older T cells have a more aged immune system.
After we controlled for poor diet and low exercise, however, the connection between stress and accelerated immune aging wasn’t as strong. This suggests that improving these health behaviors might help offset the hazards associated with stress.
Similarly, after we accounted for potential exposure to cytomegalovirus (CMV) — a common, usually asymptomatic virus known to accelerate immune aging — the link between stress and immune cell aging was reduced. Though CMV normally stays dormant in the body, researchers have found that stress can cause CMV to flare up and force the immune system to commit more resources to control the reactivated virus. Sustained infection control can use up naive T cell supplies and result in more exhausted T cells that circulate throughout the body and cause chronic inflammation, an important contributor to age-related disease.
Understanding immune aging
Our study helps clarify the association between social stress and faster immune aging. It also highlights potential ways to slow down immune aging, such as changing how people cope with stress and improving lifestyle behaviors around diet, smoking and exercise. Developing effective cytomegalovirus vaccines may also help alleviate immune system aging.
Epidemiological studies, however, cannot completely establish cause and effect. More research is needed to confirm whether stress reduction or lifestyle changes will lead to improvements in immune aging, and to better understand how stress and latent pathogens such as cytomegalovirus interact to cause illness and death. We are using additional data from the HRS to examine how these and other factors — including childhood adversity — affect immune aging over time.
Less aged immune systems are better able to fight infections and generate protective immunity from vaccines. Immunosenescence might help explain why people will probably have more severe cases of the coronavirus and a weaker response to vaccines as they age. Understanding what influences immune aging may help researchers better address age-related disparities in health and illness.“